Anhydrobiosis

نویسنده

  • David A. Wharton
چکیده

way some applicants worry. A paper in Nature, Science or Cell is not essential to get an interview. Instead, our search committees look for evidence of success as a leader of a project in different environments (e.g. the PhD and postdoc labs) — a few fi rst-author publications that push a fi eld forward in journals of reasonable reputation and outstanding letters of recommendation from multiple mentors. We are looking for applicants who can develop a good project and successfully compete for external grants once they become independent. The area of research is very important: some committees look to add hot new areas of research to a department’s current portfolio, others add to the current strengths to build a critical mass in the area, and yet others focus on match with institutional strategic plans. After these semi-objective screens, there are still 10–20 applicants who are comparable with each other and of interest to the department. This is when slight differences in letters of recommendation (or phone conversations with referees) and diversity requirements become important for determining a slightly subjective list of interviewees. At the interviews, the personality of the applicant matters signifi cantly — is s/he a good speaker, intelligent, interactive, excited about the work and a potentially good colleague? Can s/he defend his/ her ideas well? How does the applicant deal with new suggestions? These are all the same considerations as when interviewing for any job that requires high cognitive skills.

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منابع مشابه

Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach

Upon desiccation, some tardigrades enter an ametabolic dehydrated state called anhydrobiosis and can survive a desiccated environment in this state. For successful transition to anhydrobiosis, some anhydrobiotic tardigrades require pre-incubation under high humidity conditions, a process called preconditioning, prior to exposure to severe desiccation. Although tardigrades are thought to prepare...

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Multiple genes contribute to anhydrobiosis (tolerance to extreme desiccation) in the nematode Panagrolaimus superbus

The molecular basis of anhydrobiosis, the state of suspended animation entered by some species during extreme desiccation, is still poorly understood despite a number of transcriptome and proteome studies. We therefore conducted functional screening by RNA interference (RNAi) for genes involved in anhydrobiosis in the holo-anhydrobiotic nematode Panagrolaimus superbus. A new method of survival ...

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Anhydrobiosis-Associated Nuclear DNA Damage and Repair in the Sleeping Chironomid: Linkage with Radioresistance

Anhydrobiotic chironomid larvae can withstand prolonged complete desiccation as well as other external stresses including ionizing radiation. To understand the cross-tolerance mechanism, we have analyzed the structural changes in the nuclear DNA using transmission electron microscopy and DNA comet assays in relation to anhydrobiosis and radiation. We found that dehydration causes alterations in...

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Anhydrobiosis without trehalose in bdelloid rotifers.

Eukaryotes able to withstand desiccation enter a state of suspended animation known as anhydrobiosis, which is thought to require accumulation of the non-reducing disaccharides trehalose (animals, fungi) and sucrose (plants), acting as water replacement molecules and vitrifying agents. We now show that clonal populations of bdelloid rotifers Philodina roseola and Adineta vaga exhibit excellent ...

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Identification of Anhydrobiosis-related Genes from an Expressed Sequence Tag Database in the Cryptobiotic Midge Polypedilum vanderplanki (Diptera; Chironomidae)*

Some organisms are able to survive the loss of almost all their body water content, entering a latent state known as anhydrobiosis. The sleeping chironomid (Polypedilum vanderplanki) lives in the semi-arid regions of Africa, and its larvae can survive desiccation in an anhydrobiotic form during the dry season. To unveil the molecular mechanisms of this resistance to desiccation, an anhydrobiosi...

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Vitrification is essential for anhydrobiosis in an African chironomid, Polypedilum vanderplanki.

Anhydrobiosis is an extremely dehydrated state in which organisms show no detectable metabolism but retain the ability to revive after rehydration. Thus far, two hypotheses have been proposed to explain how cells are protected during dehydration: (i) water replacement by compatible solutes and (ii) vitrification. The present study provides direct physiological and physicochemical evidence for t...

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عنوان ژورنال:
  • Current Biology

دوره 25  شماره 

صفحات  -

تاریخ انتشار 2015